Bone blood flow and metabolism in humans: Effect of muscular exercise and other physiological perturbations

Journal of Bone and Mineral Research, 03/01/2013

Human bone blood flow and metabolism during physical exercise remains poorly characterised. In the present study the authors measured femoral bone blood flow and glucose uptake in young healthy subjects by positron emission tomography in three separate protocols. resting femoral bone blood flow increases by physical exercise, but appears to level off with increasing exercise intensities. Moreover, while moderate systemic hypoxia does not change bone blood flow at rest or during exercise, intra–arterially administered adenosine during resting conditions is capable of enhancing bone blood flow in humans markedly. Finally, also bone glucose uptake increases substantially in response to exercise.

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