Primary Sjogren syndrome: an update on current pharmacotherapy options and future directions

Expert Opinion on Pharmacotherapy, 02/13/2013

The overall low level of evidence in therapeutic studies in primary Sjogren syndrome (SS) suggests that much larger trials of the most promising therapies are necessary. The use of drugs targeting molecules and receptors involved in the etiopathogenesis of primary SS may open up a new era in the therapeutic management of the disease, but the potential risks and benefits of these agents must be weighed carefully.

  • Treatment of sicca manifestations is symptomatic and is based on the administration of topical therapies (saliva substitutes and preservative-free artificial tears).
  • In severe cases of keratoconjunctivitis sicca, topical cyclosporine A may be used.
  • For patients with residual salivary gland function, stimulation of salivary flow with a sialogogue (pilocarpine or cevimeline) is the treatment of choice.
  • The management of extraglandular features must be tailored to the specific organ(s) involved.
  • Hydroxychloroquine may be appropriate for patients with fatigue, arthralgia and myalgia, while glucocorticoids and immunosuppressive agents should be reserved for severe systemic involvement (although no controlled trials in primary SS guide their use).
  • RCTs have demonstrated the lack of efficacy of antitumor necrosis factor agents and promising results for B-cell depleting agents.

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