Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia
Pediatric Blood & Cancer, 08/10/2012
Gordijn MS et al. – Differences in parental and self–reports, including worse parental ratings, might be explained by worried parents and/or the adaptive style of the children. Impaired sleep and fatigue correlated with more depressive symptoms and a worse quality of life (QoL).Methods
- Sleep, fatigue, depression, and QoL were evaluated by parent proxy and/or child self-reports of the Children's Sleep Habits Questionnaire, the PedsQL multidimensional fatigue scale, the Children's Depression Inventory and the Child Health Questionnaire.
- All total scores were compared to Dutch norm references.
- Sixty-two children were included, being 36 (interquartile range 22–62)months after finishing treatment.
- Parents rated the ALL survivors as having more disturbed sleep, more fatigue and poorer physical QoL compared to the Dutch norm.
- ALL survivors themselves reported less sleep problems, less depressive symptoms, and better psychosocial QoL than the Dutch norm.
- More sleep disturbances and fatigue correlated with more symptoms of depression and a worse QoL.