A Comparison of Bone Mineral Density in Normal Weight and Obese Adolescents with Polycystic Ovary Syndrome
Journal of Pediatric and Adolescent Gynecology , 07/27/2012
To WWK et al. – Normal weight polycystic ovary syndrome (PCOS) adolescents with oligo/amenorrhea have marginally lower bone mineral density (BMD) values than controls, but obese PCOS adolescents have BMD values compatible with eumenorrheic adolescents.Methods
- Subjects consisted of adolescents between 16 to 18 years of age presenting with oligo/ amenorrhea with ultrasound morphology of polycystic ovaries ± evidence of hyperandrogenism over 24 months.
- Controls consisted of consecutive eumenorrheic patients within the same age group.
- All underwent full hormonal profile assessment, and dual energy X–ray absorptiometry and peripheral quantitative computed tomography scans.
- Of 37 adolescents with PCOS, 12 (32%) were obese with BMI ≥25, of which 9/12 (75%) were hyperandrogenic.
- The control group consisted of 40 normal weight eumenorrheic girls.
- The PCOS group overall had lower lumbar spine BMD values as compared to the controls (0.91 vs 0.97 g/ cm2, P = 0.033).
- The normal weight PCOS group had lower BMD at the spine (0.90 vs 0.97 g/ cm2, P = 0.027), trochanter (0.66 vs 0.71 g/ cm2, P = 0.039) as well as volumetric distal tibial core sites (268 vs 296 mg/ cm3) as compared to eumenorrheic controls, but there were no significant BMD differences between the obese PCOS group and the eumenorrheic controls.