Second pregnancy outcomes for women with systemic lupus erythematosus
Annals of Rheumatic Diseases, 07/11/2012
Shand AW et al. – Women with Systemic lupus erythematosus (SLE) are at high risk of adverse pregnancy outcomes. However, those who have a perinatal death in their first pregnancy can expect a live birth for a subsequent pregnancy.Methods
- A population–based cohort study was carried out of 794 577 deliveries to 532 612 women giving birth in New South Wales, Australia from 2001 to 2009.
- Data were obtained from longitudinally linked birth records and hospital records.
- 675 women had a diagnosis of SLE in the study period (prevalence 127 per 100 000 childbearing women).
- Of 177 women who had a first nulliparous birth and subsequent pregnancy, 10 (5.6%) had a perinatal death in the first pregnancy, and of these women, 9 (90%) had a baby discharged home alive in the second pregnancy.
- Of the 167 women whose first–birth infants survived, second pregnancy outcomes included: 18 (11%) admission for spontaneous abortion, 1 perinatal death (0.6%) and 148 (89%) infants discharged home.
- Two women had a thromboembolic event in their first pregnancy but had no thromboembolic event in the second.
- Two women had thromboembolic events in second pregnancies only.