Correlations between histopathologic and scintigraphic parameters of salivary glands in patients with Sjögrens syndrome
Clinical Rheumatology, 07/11/2012
Aksoy T et al. – Decreased EF in the salivary glands is correlated with the Sjögren’s syndrome (SS), and salivary gland scintigraphy is a sensitive and valid method for evaluation of the function of the salivary glands.Methods
- Thirty patients suspected of having SS referred to the clinic for salivary gland scintigraphy were included to this study.
- All patients underwent salivary gland biopsy as well.
- The severity of histopathologic changes was graded according to the Chisholm and Mason scoring system.
- Dynamic scintigraphy was performed and region of interests (ROI) were drawn.
- Time activity curves for salivary glands were generated.
- Count rates of maximum, minimum activity after lemon juice stimuli, and last minute activities of parotid and submandibular glands were obtained.
- On the basis of this ROI counts, excretion fraction (EF%) was calculated for all salivary glands.
- The mean EF% for normal parotid gland and pathologic parotid gland was 54.5 ± 13.9 and 45.8 ± 18.42, respectively, while it was 46.7 ± 11.7 for the normal submandibular gland and 29.3 ± 18.8 for the pathologic submandibular gland.
- With progression in histopathologic grades from 0 to 4, the EF decreased in all salivary glands.