Osteoporosis in young adults: pathophysiology, diagnosis, and management
Osteoporosis International,

Ferrari S et al. – The International Osteoporosis Foundation (IOF) convened a working group to review pathophysiology, diagnosis, and management of osteoporosis in the young, excluding children and adolescents, and provide a screening strategy including laboratory exams for a systematic approach of this condition.

  • Postmenopausal osteoporosis is mainly caused by increased bone remodeling resulting from estrogen deficiency.
  • Indications for treatment are based on low areal bone mineral density (aBMD, T–score≤–2.5), typical fragility fractures (spine or hip), and more recently, an elevated 10–year fracture probability (by FRAX).
  • In contrast, there is no clear definition of osteoporosis nor intervention thresholds in younger individuals.
  • Low aBMD in a young adult may reflect a physiologically low peak bone mass, such as in lean but otherwise healthy persons, whereas fractures commonly occur with high–impact trauma, i.e., without bone fragility.
  • Furthermore, low aBMD associated with vitamin D deficiency may be highly prevalent in some regions of the world.
  • Nevertheless, true osteoporosis in the young can occur, which the authors define as a T–score below -2.5 at spine or hip in association with a chronic disease known to affect bone metabolism.
  • In the absence of secondary causes, the presence of fragility fractures, such as in vertebrae, may point towards genetic or idiopathic osteoporosis. In turn, treatment of the underlying condition may improve bone mass as well.
  • In rare cases, a bone–specific treatment may be indicated, although evidence is scarce for a true benefit on fracture risk.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

1 Immune fault linked to disease University of Edinburgh College of Medicine News, December 1, 2014

2 A combination of celecoxib and famciclovir is efficacious in the treatment of fibromyalgia: Results of a phase IIa randomized, double-blind, placebo-controlled study American College of Rheumatology News, December 2, 2014    Clinical Article

3 The association of serum anti-ribosomal P antibody with clinical and serological disorders in systemic lupus erythematosus: A systematic review and meta-analysis Lupus, November 26, 2014    Evidence Based Medicine    Review Article

4 Coffee or tea consumption and the risk of rheumatoid arthritis: A meta-analysis Clinical Rheumatology, October 15, 2014    Clinical Article

5 Blood test could prevent medication trial and error for rheumatoid arthritis patients Mayo Clinic, November 18, 2014

6 The comparative safety of TNF inhibitors in rheumatoid arthritis - a meta-analysis update of 44 randomized controlled trials American Journal of Medicine, October 6, 2014    Clinical Article

7 Long-term follow-up of patients who received repeat-dose rituximab as maintenance therapy for ANCA-associated vasculitis Rheumatology, December 8, 2014    Clinical Article

8 Yearly treatment could slow osteoarthritis Monash University News, September 23, 2014

9 Ten common mistakes in the management of lupus nephritis American Journal of Kidney Diseases, January 3, 2014    Clinical Article

10 Tramadol and risk of hospitalization for hypoglycemia McGill University News, December 10, 2014

11 Methotrexate and lung disease in rheumatoid arthritis – A meta-analysis of randomized controlled trials Arthritis & Rheumatism, December 27, 2013    Evidence Based Medicine    Review Article    Clinical Article

12 Mayo Clinic researchers: TNF inhibitors may increase cancer risk in the eye Mayo Clinic, November 19, 2014

13 Lupus enteritis: Clinical characteristics and predictive factors for recurrence Lupus, December 4, 2014    Clinical Article

14 Safety and efficacy of ifalimumab, an anti IFN-alpha monoclonal antibody, in a phase 2b study of moderate to severe systemic lupus erythematosus American College of Rheumatology News, November 25, 2014

15 Diagnostic value of the anti-Sa antibody compared with the anti-cyclic citrullinated peptide antibody in rheumatoid arthritis International Journal of Rheumatic Diseases, December 11, 2014    Clinical Article

16 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 8, 2014    Evidence Based Medicine    Review Article

17 Second-line agents in myositis: 1-year factorial trial of additional immunosuppression in patients who have partially responded to steroids Rheumatology, December 10, 2014    Clinical Article

18 Adalimumab for steroid sparing in patients with giant-cell arteritis: Results of a multicentre randomised controlled trial Annals of Rheumatic Diseases, November 10, 2014    Clinical Article

19 Electrical stimulation for pain relief in knee osteoarthritis: Systematic review and network meta-analysis Osteoarthritis and Cartilage , December 4, 2014    Evidence Based Medicine    Review Article

20 Current evidence on risk factors for knee osteoarthritis in older adults: A systematic review and meta-analysis Osteoarthritis and Cartilage , December 2, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List