Autoantibodies to citrullinated fibrinogen compared with anti-MCV and anti-CCP2 antibodies in diagnosing rheumatoid arthritis at an early stage: data from the French ESPOIR cohort
Annals of Rheumatic Diseases,

Nicaise–Roland P et al. – In early arthritis, antibodies to citrullinated fibrinogen (AhFibA), anti–MCV and anti–CCP2 showed similar diagnostic sensitivity with a high diagnostic specificity and a similar high positive predictive value for rheumatoid arthritis (RA). Adding anticitrullinated peptides/protein antibodies (ACPA) to the 1987 ACR criteria significantly increased the number of patients classified as having RA, confirming the validity of the recent inclusion of the serological criterion in the ACR/EULAR criteria.

Methods
  • A diagnosis of RA (1987 American College of Rheumatology (ACR) criteria) was established at baseline in 497 patients and after a 2–year follow–up in 592 patients.
  • At baseline, antibodies to citrullinated fibrinogen (AhFibA), antimutated citrullinated vimentin (anti–MCV) and anticyclic citrullinated peptide (anti–CCP2) were assayed and the individual and combined diagnostic sensitivities and predictive values of the tests were determined.
  • Relationships between ACPA positivity and the 28–joint disease activity score and Health Assessment Questionnaire scores were analysed.

Results
  • At a diagnostic specificity of at least 98%, the three tests exhibited similar diagnostic sensitivities (47–48.5%).
  • When considering as positive patients with at least one positive test, the sensitivity increased to 53.5% with a probable loss of specificity.
  • Among the patients classified as having UA at baseline, 30% were positive for one ACPA, the positive predictive values for RA of the three tests ranging from 73% to 80% but increasing when two tests were associated.
  • Whatever the test used, the addition of ACPA positivity to the 1987 criteria enhanced their sensitivity by 6%, close to that of the 2010 ACR/European League Against Rheumatism (EULAR) criteria.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

1 Rituximab vs mycophenolate and vs cyclophosphamide pulses for induction therapy of active lupus nephritis: A clinical observational study Rheumatology, February 11, 2014    Clinical Article

2 Methotrexate and lung disease in rheumatoid arthritis – A meta-analysis of randomized controlled trials Arthritis & Rheumatism, December 27, 2013    Evidence Based Medicine    Review Article    Clinical Article

3 Risk of malignancy in patients with giant cell arteritis and polymyalgia rheumatica: A systematic review and meta-analysis Seminars in Arthritis and Rheumatism, June 27, 2014    Evidence Based Medicine    Review Article

4 Identification of lymphoma predictors in patients with primary Sjögren's syndrome: A systematic literature review and meta-analysis Rheumatology International, June 5, 2014    Evidence Based Medicine    Review Article

5 Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: A prospective, case-control study Annals of Rheumatic Diseases, June 25, 2014    Clinical Article

6 Ten common mistakes in the management of lupus nephritis American Journal of Kidney Diseases, January 3, 2014    Clinical Article

7 Intra articular injection with corticosteroids in patients with recent onset rheumatoid arthritis: subanalyses from the BeSt study Clinical Rheumatology, February 17, 2014    Clinical Article

8 Ten-year followup of infliximab therapy in rheumatoid arthritis patients with severe, longstanding refractory disease: a cohort study The Journal of Rheumatology, June 2, 2014    Clinical Article

9 Pregnancy in adult-onset idiopathic inflammatory myopathy: Report from a cohort of myositis patients from a single center Seminars in Arthritis and Rheumatism, June 4, 2014    Clinical Article

10 Is the risk of tumour necrosis factor inhibitor-induced lupus or lupus-like syndrome the same with monoclonal antibodies and soluble receptor? A case/non-case study in a nationwide pharmacovigilance database Rheumatology, June 12, 2014    Clinical Article

11 Reading of sacroiliac joints on plain pelvic radiographs: Agreement between clinical practice and trained central reading. Results of the DESIR-cohort Arthritis & Rheumatism, June 11, 2014    Clinical Article

12 Efficacy and safety of loxoprofen hydrogel patch versus loxoprofen tablet in patients with knee osteoarthritis: A randomized controlled non-inferiority trial Clinical Rheumatology, June 17, 2014    Clinical Article

13 Low-dose aspirin use and recurrent gout attacks Annals of Rheumatic Diseases, January 7, 2014    Clinical Article

14 Clinical efficacy of abatacept compared to adalimumab and tocilizumab in rheumatoid arthritis patients with high disease activity Clinical Rheumatology, January 15, 2014    Clinical Article

15 Ultrasonography as an additional item in the American College of Rheumatology classification of Sjogren's syndrome Rheumatology, June 16, 2014    Clinical Article

16 A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative Seminars in Arthritis and Rheumatism, December 6, 2013    Evidence Based Medicine    Review Article    Clinical Guideline    Clinical Article

17 Lifestyle interventions for acute gout Cochrane Reviews, December 10, 2013    Evidence Based Medicine    Review Article    Clinical Article

18 Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: A systematic review Seminars in Arthritis and Rheumatism, June 19, 2014    Review Article

19 The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses Rheumatology International, June 6, 2014    Clinical Article

20 Rheumatology drug updates Full Text The Rheumatologist, March 19, 2014    Free full text

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close