Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a Japanese Population
The Journal of Rheumatology,

Kiyohara C et al. – The results suggest that smoking was positively associated with increased systemic lupus erythematosus (SLE) risk whereas light/moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage. Additional studies are warranted to confirm these findings.

Methods
  • The authors investigated the relationship of smoking and drinking compared to SLE risk among 171 SLE cases and 492 healthy controls in female Japanese subjects.
  • Unconditional logistic regression was used to compute OR and 95% CI, with adjustments for several covariates.

Results
  • Compared with nonsmoking, current smoking was significantly associated with increased risk of SLE (OR 3.06, 95% CI 1.86–5.03).
  • The higher the level of exposure to cigarette smoke, the higher the risk of SLE.
  • Inhalation was also associated with increased SLE risk (OR 3.73, 95% CI 1.46–9.94 for moderate inhalation; OR 3.06, 95% CI 1.81–5.15 for deep inhalation).
  • In contrast, light/moderate alcohol consumption had a protective effect on SLE risk (OR 0.38, 95% CI 0.19–0.76).
  • As for beer, the risks for non–beer drinkers and beer drinkers were similar.
  • This also applies to alcoholic beverages other than beer.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

1 Homeopathy in the treatment of fibromyalgia- A comprehensive literature-review and meta-analysis Complementary Therapies in Medicine, August 15, 2014    Evidence Based Medicine    Review Article

2 Coffee or tea consumption and the risk of rheumatoid arthritis: A meta-analysis Clinical Rheumatology, October 15, 2014    Clinical Article

3 The comparative safety of TNF inhibitors in rheumatoid arthritis - a meta-analysis update of 44 randomized controlled trials American Journal of Medicine, October 6, 2014    Clinical Article

4 Drug-associated cutaneous vasculitis: Study of 239 patients from a single referral center The Journal of Rheumatology, September 25, 2014    Clinical Article

5 Rituximab for the treatment of relapses in ANCA-associated vasculitis Arthritis & Rheumatism, August 1, 2014    Clinical Article

6 Lupus classification criteria expanded; treat-to-target approach gains support Full Text The Rheumatologist, July 24, 2014    Free full text

7 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 8, 2014    Evidence Based Medicine    Review Article

8 The impact of statins therapy on disease activity and inflammatory factor in patients with rheumatoid arthritis: A meta-analysis Clinical and Experimental Rheumatology Online, October 27, 2014    Evidence Based Medicine    Clinical Article

9 Efficacy and safety of ginger in osteoarthritis patients: A meta-analysis of randomized placebo-controlled trials Osteoarthritis and Cartilage , October 28, 2014    Evidence Based Medicine    Clinical Article

10 Early predictors of prognosis in juvenile idiopathic arthritis: A systematic literature review Annals of Rheumatic Diseases, August 29, 2014    Review Article

11 Homeopathy in the treatment of fibromyalgia—A comprehensive literature-review and meta-analysis Complementary Therapies in Medicine, October 9, 2014    Clinical Article

12 Alcohol consumption as a preventive factor for developing rheumatoid arthritis: A dose-response meta-analysis of prospective studies Annals of Rheumatic Diseases, October 24, 2014    Evidence Based Medicine    Clinical Article

13 Cost-utility of cognitive behavioural therapy versus U.S. food and drug administration recommended drugs and usual care in the treatment of patients with fibromyalgia: An economic evaluation alongside a 6-month randomised controlled trial Arthritis Research & Therapy, October 7, 2014    Clinical Article

14 Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive joint damage in rheumatoid arthritis patients International Journal of Rheumatic Diseases, October 17, 2014    Clinical Article

15 Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless of initial infliximab: The 5-year follow-up results of a randomised clinical trial, the NEO-RACo trial Annals of Rheumatic Diseases, October 23, 2014    Clinical Article

16 Low-dose pulse cyclophosphamide in interstitial lung disease associated with systemic sclerosis (SSc-ILD) - efficacy of maintenance immunosuppression in responders and non-responders Seminars in Arthritis and Rheumatism, September 30, 2014    Clinical Article

17 Vitamin D deficiency is associated with progression of knee osteoarthritis The Journal of Nutrition, October 10, 2014    Clinical Article

18 Oral bisphosphonate use and total knee/hip implant survival: Validation of results in an external population-based cohort Arthritis & Rheumatism, August 14, 2014    Clinical Article

19 Lipid profile changes in patients with chronic inflammatory arthritis treated with biologics and tofacitinib in randomized clinical trials: A systematic review and meta-analysis Arthritis & Rheumatism, October 14, 2014    Evidence Based Medicine    Review Article

20 Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: A randomized double-blind placebo-controlled study Full Text Open Access Rheumatology: Research and Reviews, October 13, 2014    Free full text    Clinical Article

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore