Pattern Differentiation in Traditional Chinese Medicine Can Help Define Specific Indications for Biomedical Therapy in the Treatment of Rheumatoid Arthritis
The Journal of Alternative and Complementary Medicine,  Clinical Article

Lu C et al. – Traditional Chinese Medicine (TCM) pattern differentiation based on symptoms can help identify a subset of patients with Rheumatoid Arthritis (RA) that will more likely respond to biomedical therapy, consisting of diclofenac, methotrexate, and sulfasalazine.

Methods
  • This study uses data from a previous multicenter randomized–controlled clinical trial.
  • One hundred and ninety–four (194) patients were treated with biomedical combination therapy (diclofenac, methotrexate, and sulfasalazine).
  • ACR20 response at 12 weeks and 24 weeks was used for evaluation of efficacy.
  • Eight (8) symptoms, which are the most important for establishing TCM cold and hot patterns in patients with RA, were analyzed in this study.
  • TCM patterns were obtained using factor analysis of the eight symptoms.
  • Thirst, vexation, hot feeling in the joints, turbid yellow–colored urine, and fever were classified as factor 1.
  • Cold feeling in the whole body, cold feeling in the limbs, and cold feeling in the joints were classified as factor 2.
  • The classification into factor 1 and 2 is similar to TCM hot pattern and cold pattern differentiation, since the symptoms in factor 1 and 2 are the key symptoms in TCM hot and cold patterns, respectively.
  • The effective rates in patients with different TCM patterns were analyzed with the χ2 method.

Results
  • At 12 weeks, ACR20 response in patients treated with the biomedical combination therapy was 36.08%.
  • At 24 weeks, ACR20 response was 69.59%.
  • Based on the eight symptoms used in factor analysis, the effective rates in the patients with cold pattern and hot pattern were 51.67% and 29.09%, respectively, after 12 weeks of treatment; and 88.52% and 55.36%, respectively, after 24 weeks of treatment.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

1 Coffee or tea consumption and the risk of rheumatoid arthritis: A meta-analysis Clinical Rheumatology, October 15, 2014    Clinical Article

2 Mayo Clinic researchers: TNF inhibitors may increase cancer risk in the eye Mayo Clinic, November 19, 2014

3 Homeopathy in the treatment of fibromyalgia- A comprehensive literature-review and meta-analysis Complementary Therapies in Medicine, August 15, 2014    Evidence Based Medicine    Review Article

4 Blood test could prevent medication trial and error for rheumatoid arthritis patients Mayo Clinic, November 18, 2014

5 Comparison of the effects of three oral bisphosphonate therapies on the peripheral skeleton in postmenopausal osteoporosis: The TRIO study Osteoporosis International, November 12, 2014    Clinical Article

6 Adalimumab for steroid sparing in patients with giant-cell arteritis: Results of a multicentre randomised controlled trial Annals of Rheumatic Diseases, November 10, 2014    Clinical Article

7 New treatments for inflammatory rheumatic disease Immunologic Research, November 17, 2014    Review Article

8 Rituximab vs mycophenolate and vs cyclophosphamide pulses for induction therapy of active lupus nephritis: A clinical observational study Rheumatology, February 11, 2014    Clinical Article

9 Sustained remission with etanercept tapering in early rheumatoid arthritis New England Journal of Medicine, November 10, 2014    Evidence Based Medicine    Clinical Article

10 The comparative safety of TNF inhibitors in rheumatoid arthritis - a meta-analysis update of 44 randomized controlled trials American Journal of Medicine, October 6, 2014    Clinical Article

11 Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: An observational cohort study Rheumatology, August 12, 2014    Clinical Article

12 Three decades of low-dose methotrexate in rheumatoid arthritis: Can we predict toxicity? Immunologic Research, November 17, 2014    Review Article    Clinical Article

13 Comparison of the efficacy, adverse effects and cost of zoledronic acid and denosumab in the treatment of osteoporosis Endocrine Practice, November 7, 2014    Review Article

14 Clinical and radiographic outcomes at 2 years and the effect of tocilizumab discontinuation following sustained remission in the second and third year of the ACT-RAY study Annals of Rheumatic Diseases, November 18, 2014    Clinical Article

15 A double-blind, placebo-controlled, randomized, 12-week, dose-ranging study of VX-509 (decernotinib), an oral selective janus kinase 3 (JAK3) inhibitor, as monotherapy in patients with active rheumatoid arthritis Arthritis & Rheumatism, November 14, 2014    Clinical Article

16 Yearly treatment could slow osteoarthritis Monash University News, September 23, 2014

17 Intra articular injection with corticosteroids in patients with recent onset rheumatoid arthritis: subanalyses from the BeSt study Clinical Rheumatology, February 17, 2014    Clinical Article

18 Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised Phase IIb study Annals of Rheumatic Diseases, August 12, 2014    Clinical Article

19 Drug-associated cutaneous vasculitis: Study of 239 patients from a single referral center The Journal of Rheumatology, September 25, 2014    Clinical Article

20 Study by UCLA scientists reveals new findings about cause of lesions around jaw bone UCLA Health System, November 26, 2014

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore