Pattern Differentiation in Traditional Chinese Medicine Can Help Define Specific Indications for Biomedical Therapy in the Treatment of Rheumatoid Arthritis
The Journal of Alternative and Complementary Medicine,  Clinical Article

Lu C et al. – Traditional Chinese Medicine (TCM) pattern differentiation based on symptoms can help identify a subset of patients with Rheumatoid Arthritis (RA) that will more likely respond to biomedical therapy, consisting of diclofenac, methotrexate, and sulfasalazine.

Methods
  • This study uses data from a previous multicenter randomized–controlled clinical trial.
  • One hundred and ninety–four (194) patients were treated with biomedical combination therapy (diclofenac, methotrexate, and sulfasalazine).
  • ACR20 response at 12 weeks and 24 weeks was used for evaluation of efficacy.
  • Eight (8) symptoms, which are the most important for establishing TCM cold and hot patterns in patients with RA, were analyzed in this study.
  • TCM patterns were obtained using factor analysis of the eight symptoms.
  • Thirst, vexation, hot feeling in the joints, turbid yellow–colored urine, and fever were classified as factor 1.
  • Cold feeling in the whole body, cold feeling in the limbs, and cold feeling in the joints were classified as factor 2.
  • The classification into factor 1 and 2 is similar to TCM hot pattern and cold pattern differentiation, since the symptoms in factor 1 and 2 are the key symptoms in TCM hot and cold patterns, respectively.
  • The effective rates in patients with different TCM patterns were analyzed with the χ2 method.

Results
  • At 12 weeks, ACR20 response in patients treated with the biomedical combination therapy was 36.08%.
  • At 24 weeks, ACR20 response was 69.59%.
  • Based on the eight symptoms used in factor analysis, the effective rates in the patients with cold pattern and hot pattern were 51.67% and 29.09%, respectively, after 12 weeks of treatment; and 88.52% and 55.36%, respectively, after 24 weeks of treatment.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Rheumatology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Rheumatology Articles

1 Homeopathy in the treatment of fibromyalgia- A comprehensive literature-review and meta-analysis Complementary Therapies in Medicine, August 15, 2014    Evidence Based Medicine    Review Article

2 Lupus classification criteria expanded; treat-to-target approach gains support Full Text The Rheumatologist, July 24, 2014    Free full text

3 Rituximab for the treatment of relapses in ANCA-associated vasculitis Arthritis & Rheumatism, August 1, 2014    Clinical Article

4 Oral bisphosphonate use and total knee/hip implant survival: Validation of results in an external population-based cohort Arthritis & Rheumatism, August 14, 2014    Clinical Article

5 Gout, urate lowering therapy and uric acid levels among US adults Arthritis Care & Research , September 16, 2014    Clinical Article

6 Frequent conversion of tuberculosis screening tests during anti-tumour necrosis factor therapy in patients with rheumatic diseases Annals of Rheumatic Diseases, September 10, 2014    Clinical Article

7 Does non-erosive rheumatoid arthritis exist? a cross-sectional analysis and a systematic literature review Seminars in Arthritis and Rheumatism, September 25, 2014    Review Article

8 Valgus bracing for knee osteoarthritis: A meta-analysis of randomized trials Arthritis Care & Research , September 12, 2014    Evidence Based Medicine

9 Early predictors of prognosis in juvenile idiopathic arthritis: A systematic literature review Annals of Rheumatic Diseases, August 29, 2014    Review Article

10 Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritis BMJ Open, September 12, 2014    Clinical Article

11 Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: A systematic review and network metaanalysis The Journal of Rheumatology, September 18, 2014    Evidence Based Medicine    Review Article

12 Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: A randomised, multicentre, double-blind, placebo-controlled trial Annals of Rheumatic Diseases, August 25, 2014    Clinical Article

13 Profound reduction in hospital admissions and musculoskeletal surgical procedures for rheumatoid arthritis with concurrent changes in clinical practice (1995-2010) Rheumatology, September 26, 2014    Clinical Article

14 Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources Seminars in Arthritis and Rheumatism, September 29, 2014    Clinical Article

15 Differentiation between osteoarthritis and psoriatic arthritis: Implications for pathogenesis and treatment in the biological therapy era Rheumatology, September 22, 2014    Review Article

16 Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis Full Text BMC Complementary and Alternative Medicine, September 8, 2014    Free full text    Evidence Based Medicine    Review Article

17 Drug-associated cutaneous vasculitis: Study of 239 patients from a single referral center The Journal of Rheumatology, September 25, 2014    Clinical Article

18 “Worm pill” could ease autoimmune disease symptoms Monash University News, August 12, 2014

19 Comparison of the efficacy and safety of two starting dosages of prednisolone in early active rheumatoid arthritis (CORRA): study protocol for a randomized controlled trial Full Text Trials, September 18, 2014    Free full text    Evidence Based Medicine    Clinical Article

20 A possible link between ankylosing spondylitis and periodontitis: A systematic review and meta-analysis Rheumatology, September 16, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Rheumatology: Arthritis & Rheumatism, Annals of Rheumatic Diseases, Journal of Rheumatologymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close