Coexistence of polymyositis and familial Mediterranean fever
Modern Rheumatology, 05/11/2012
Eguchi M et al. – In this case report, the authors report a Japanese female patient with polymyositis (PM) who presented with periodic fever. Genetic analysis revealed that she had compound heterozygous mutations in exon 2 of the MEFV gene (L110P/E148Q/R202Q). Treatment with colchicines (1.0 mg/day) successfully eliminated febrile attack and normalized the elevated levels of neutrophil CD64 expression, leading to the diagnosis of Familial Mediterranean fever (FMF). The association of FMF and PM has not previously been reported, so they discuss this rare association.