The assessment of biologic treatment in patients with rheumatoid arthritis using FDG-PET/CT
Okamura K et al. – The FDG uptake observed in the inflamed RA joints may reflect disease activity. The FDG–PET response was correlated with the clinical response to the biologic treatment of RA.
Twenty–two patients who received anti–TNF therapies, including infliximab for 16 patients and etanercept for 6 patients, were assessed.
PET with 18F–FDG studies and clinical assessments were performed at baseline and 6 months after the initiation of therapy.
The maximal standardized uptake value (SUVmax) was used as a representative value for the assessment of the FDG uptake in the bilateral shoulder, elbow, wrist, hip, knee and ankle joints.
Spearman’s rank correlation test was applied to assess the correlation between the SUV and the clinical parameters.
The ΔSUV (12 joints), the difference in the SUVmax of the affected 12 joints before and after treatment, was positively correlated with the ΔDAS28 (r = 0.609, P = 0.003), ΔDAS28–CRP (r = 0.656, P = 0.001) and Δtender joint count (TJC) (r = 0.609, P = 0.003).
There were also significantly positive correlations between ΔSUV (8 joints); the difference in the SUVmax of the bilateral shoulder, elbow, wrist and knee joints before and after treatment and the ΔDAS28 (r = 0.642, P = 0.001), ΔDAS28–CRP (r = 0.712, P < 0.001) and ΔTJC (r = 0.608, P = 0.003), respectively.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.