Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading

Journal of Bone and Mineral Research, 08/14/2013

The Wnt/β–catenin signaling pathway is essential for bone cell viability, function and for skeletal integrity. The data show that deleting a single copy of β–catenin in osteocytes abolishes the anabolic response to loading and that trabecular bone in females is more severely affected and suggest that a critical threshold of β–catenin is required for bone formation in response to mechanical loading.

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