Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation

Journal of Bone and Mineral Research,

Type II collagen is a key cartilaginous extracellular protein required for normal endorchondral development and cartilage homeostasis. COL2A1 gene expression is positively regulated by the NAD–dependent protein deacetylase SirT1, through its ability to bind chromatin regions of the COL2A1 promoter and enhancer. The study indicates that Set7/9 prevents the histone deacetylase activity of SirT1, potentiating euchromatin formation on the promoter site of COL2A1 and resulting in morphology–dependent COL2A1 gene transactivation.

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