Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age
Journal of Bone and Mineral Research, 06/13/2013Jilka RL et al.
Skeletal aging is accompanied by decreased cancellous bone mass and increased formation of pores within cortical bone. Increasing bone mass by artificial prolongation of the inherent lifespan of short–lived osteoblasts, while exaggerating the adverse effects of aging on long–lived osteocytes, highlights the seminal role of cell age in bone homeostasis. In addition, the findings suggest that distress signals produced by old and/or dysfunctional osteocytes are the culprits of the increased intracortical porosity in old age.
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