p130Cas plays important roles in osteoclastic bone resorption

Journal of Bone and Mineral Research, 03/26/2013

p130Cas, Crk–associated substrate (Cas), is an adaptor/scaffold protein that plays a central role in actin cytoskeletal reorganization. The authors previously reported that p130Cas is not tyrosine–phosphorylated in osteoclasts derived from Src–deficient experimental models, which are congenital osteopetrotic, suggesting that p130Cas serves as a downstream molecule of c–Src and is involved in osteoclastic bone resorption. The results strongly indicate that p130Cas plays pivotal roles in osteoclastic bone resorption.

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