Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using rBMP-2

Journal of Bone and Mineral Research, 03/01/2013

The aim of the present study was to assess the bone regeneration process in defects introduced into rabbit long bones, which were regenerated with controlled release of recombinant bone morphogenetic protein–2 (rBMP–2). Preferential BAp c–axis orientation is a strong determinant and predictor of the mechanical function of tissue–engineered bone. Therefore, analysis of BAp preferential c–axis orientation in addition to measurement of BMD is crucial in assessment of bone mechanical function.

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