Early diagnosis to enable early treatment of pre-osteoarthritis
Arthritis Research & Therapy, 06/08/2012
Chu CR et al. – This review focuses on recent advances in imaging and biochemical biomarkers suitable for characterization of the pre–osteoarthritic joint as well as implications for development of effective early treatment strategies.
Osteoarthritis is a highly prevalent and disabling disease affecting an increasingly large swathe of the world population.
While clinical osteoarthritis is a late stage condition for which opportunities for disease modification are limited, osteoarthritis typically progresses to a symptomatic clinically identifiable state over several decades offering a long window of opportunity for altering its course.
The etiology of osteoarthritis is multi–factorial with stronger associations to highly modifiable risk factors of mechanical overload and trauma than to genetic predisposition.
As such, characterization of early pre–osteoarthritic disease states will be critical towards supporting a paradigm shift from modification of traditional clinical osteoarthritis to early diagnosis and early treatment of joint injury and degeneration to prevent or delay the onset of osteoarthritis.
Joint trauma accelerates development of clinical osteoarthritis and provides a unique opportunity for evaluation of pre–osteoarthritic conditions from its earliest stages.
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