Quadriceps Muscle Weakness, Activation Deficits, and Fatigue With Parkinson Disease

Neurorehabilitation and Neural Repair, 05/16/2012

The findings provide additional evidence for lower–extremity strength loss with Parkinson disease (PD); central activation deficits may account for some of the strength deficits, especially with increased PD motor signs. Also, muscle fatigue did not occur in individuals with a greater degree of PD motor signs, most likely because of insufficient central activation to allow for muscle overload to induce metabolic fatigue.

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