Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis
Genes and Immunity, 05/11/2012
McKinney C et al. – Although requiring replication, these results suggest that impaired immune complex clearance arising from FCGR3B deficiency contributes to the pathology of systemic sclerosis (SSc), and FCGR3B copy number (CN) variation is a common risk factor for systemic autoimmunity.
The authors hypothesised that FCGR3B gene dosage influences susceptibility to SSc.
The authors obtained FCGR3B deletion status in 777 European Caucasian cases and 1000 controls.
There was an inverse relationship between FCGR3B CN and disease susceptibility.
CN of 1 was a significant risk factor for SSc (OR=1.55 (1.13–2.14), P=0.007) relative to CN2.
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