Association of dietary magnesium intake with radiographic knee osteoarthritis: The johnston county osteoarthritis project
Arthritis Care & Research , 04/24/2012
Qin B et al. – A modest inverse threshold association was found between dietary Mg intake and knee osteoarthritis (OA) in Caucasians but not in African Americans.
The presence of radiographic knee OA was examined among participants from the Johnston County Osteoarthritis Project (JoCo OA) and was defined as Kellgren–Lawrence (K–L) grade of at least 2 in at least one knee.
The Block Food Frequency Questionnaire (FFQ) was used to assess Mg intake.
Effect modifiers were explored by testing interactions of Mg intake and selected factors based on previous literature.
The multivariable logistic regression model with standard energy adjustment method was used to estimate the relation of Mg intake and radiographic knee OA.
The prevalence of knee OA was 36.27% among 2112 participants.
The relation of Mg intake and radiographic knee OA was found to be modified by race (P for interaction = 0.03).
An inverse threshold association was observed among Caucasians.
Comparing to those in the lowest quintile, the relative odds of radiographic knee OA was cut by half for participants in the second quintile of Mg intake (OR: 0.52; 95% CI 0.34–0.79); further Mg intake did not provide further benefits (P for trend = 0.51).
A statistically significant association was not observed among African Americans.
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