A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

Annals of Rheumatic Diseases, 04/09/2012

The results suggest that a variant in PCSK6 is strongly associated with protection against pain in knee osteoarthritis (OA), offering some insight as to why, in the presence of the same structural damage, some individuals develop chronic pain and others are protected. Studies in Pcsk6 null mutant mice further implicate PACE4 in pain.

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