A population-based 2-year follow-up study on the relationship between bisphosphonates and the risk of stroke
Osteoporosis International, 02/06/2012
Kang JH et al. – Patients who received bisphosphonate therapy were associated with a lower risk of stroke during a 2-year follow-up period.
Identified 2,148 patients who received bisphosphonate therapy for osteoporotic fractures
Randomly extracted 6,444 subjects with vertebral or hip fractures as comparison group matched with study group on age, sex, and year of index date
Each patient was individually tracked for 2 years to identify those who suffered a stroke
Stratified Cox proportional hazards regressions were performed to assess the effect of bisphosphonate treatment on the risk of stroke
Found that 184 (8.6%) patients who received bisphosphonate therapy and 696 (10.8%) comparison patients suffered a stroke during follow-up period
After adjusting for demographic variables and medical co-morbidities, stratified Cox proportional hazards regressions stratified by propensity score revealed that patients who received bisphosphonate therapy were less likely to suffer a stroke than comparison patients (HR equals 0.79; 95% CI equals 0.66–0.99)
Adjusted HR for subarachnoid/intra-cerebral hemorrhage for patients who received bisphosphonate therapy was only 0.53 times (95% CI equals 0.33–0.92) that of comparison patients, and hazard of having an ischemic stroke during the 2-year follow-up period was 0.81 times that of comparison patients (95% CI equals 0.65–0.96)
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