Chronic autoimmune urticaria as the first manifestation of juvenile systemic lupus erythematosus
Spadoni MS et al. – Chronic autoimmune urticaria is very rare and may be the first lupus manifestation, particularly associated with the presence of autoantibodies. This study reinforces the importance of a rigorous follow–up in children and adolescents suffering from autoimmune urticaria due to the possibility of connective tissue disorders, such as paediatric lupus.
During 27 consecutive years, 5419 patients were followed up at the University Hospital and 271 (5%) had juvenile SLE (American College of Rheumatology criteria).
Two of them (0.7%) had chronic and painless autoimmune urticaria as the first manifestation of juvenile SLE, and were reported herein.
One case was a five–year old female with continuous widespread urticaria (duration 120 days), antinuclear antibodies (ANA) 1:640 (dense fine speckled pattern) and elevated complement levels.
The juvenile SLE diagnosis was established after one year.
The other case was a 13–year old female who had chronic widespread urticaria (lasting 45 days), ANA 1:160 (fine speckled pattern) and normal complement levels.
The juvenile SLE diagnosis was established after three years.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.