Rheumatoid factor measurement--continuing problems 70 years after discovery
Clinical Rheumatology, 04/11/2011
Ameratunga R et al.
– Standardization for rheumatoid factor (RF) measurement is not optimal and has not been achieved between these two commonly used instruments. This may have clinical implications for patient management.
Compared RF results between 2 commonly used commercial instruments
Serum samples exchanged between laboratory using Beckman Immage immunonephelometer and another using Roche Modular immunoturbidimeter
The World Health Organization (WHO) reference standard for RF (W1066) used to compare 2 methods
The Roche immunoturbidimeter appears to have superior sensitivity
Significant bias between 2 instruments as levels of RF increase
Results from WHO RF reference preparation correlated most closely with results from Roche immunoturbidimeter
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