Efficacy of total joint arthroplasty in patients with established rheumatoid arthritis: Improved longitudinal effects on disease activity but not on health-related quality of life

Modern Rheumatology, 03/14/2011

Momohara S et al. – This study aimed to assess changes in disease activity and health-related quality of life after TJA in patients with established RA.


  • Analyzed the effect of total knee arthroplasty (TKA) and total hip arthroplasty (THA) on RA disease activity in an observational cohort of RA patients
  • Of registered RA patients, 333 TKA and 77 THA patients followed for 5 years after surgery
  • RA disease activity and health-related quality of life measured using Disease Activity Score 28 (DAS28) and Japanese version of Stanford health assessment questionnaire (J-HAQ)


  • Mean DAS28 in TKA patients decreased from 4.66 (preoperatively) to 4.02 (3 years postoperatively) and to 3.94 (5 years postoperatively); mean DAS28 in THA patients decreased from 4.41 (preoperatively) to 3.99 (3 years postoperatively) and to 3.92 (5 years postoperatively)
  • Mean J-HAQ for TKA remained essentially unchanged, ranging from 1.48 (preoperatively) to 1.45 (3 years postoperatively) and to 1.47 (5 years postoperatively); mean J-HAQ for THA also remained unchanged, ranging from 1.74 (preoperatively) to 1.74 (3 years postoperatively) and to 1.73 (5 years postoperatively)
  • Of total J-HAQ score, lower limb score improved while upper limb score worsened

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