Simple isotopic method using oral stable or radioactive tracers for estimating fractional calcium absorption in adult women
Osteoporosis International, 10/15/2010
Lee WH et al.
Fractional calcium absorption can be estimated by a single oral tracer method using either radioactive or stable calcium isotopes across the entire age spectrum in healthy white adult women.
Used database of 56 observations from 26 white adult women aged 19–67 years receiving either radioactive or stable isotopes
Reference values for fractional calcium absorption were determined from 24-h double isotopic ratios in serum and urine and from full kinetic modeling
Equations for estimating fractional calcium absorption developed from isotopic enrichment in serum and urine from an oral tracer and measures of body size using multiple linear regression analysis
Equations using a 4- to 6-h sample following an oral dose of either stable or radioactive isotope corrected for body size were highly correlated with reference values for fractional calcium absorption across different aged populations (r?>?0.8, p?0.001)
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