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Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results
European Journal of Nuclear Medicine & Molecular Imaging, 11/10/09
Klumpers UMH et al. – The bilateral reduction in limbic parahippocampal and right temporal [11C]FMZ binding found in MDD indicates decreased GABAA–benzodiazepine receptor complex affinity and/or number. The inverse relationship between GABAA binding in the temporal lobe and HPA axis activity, suggests that HPA axis hyperactivity is partly due to reduced GABA–ergic inhibition.
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