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Detection and diagnosis of Mycobacterium tuberculosis
Expert Review of Anti-infective Therapy, 11/10/09
Al–Zamel FA – The current routine diagnostic tests for TB – chest x–ray, tissue culture, tuberculin skin test and acid–fast staining – all have their limitations. A chest x–ray alone is inconclusive; a tissue culture takes too long to produce a result; the TST lacks specificity and reliability; and acid–fast staining depends on a large number of bacteria in the sputum to give an accurate reading. New methods have been developed, such as nucleic acid amplification technology which, although specific, can yield false–positive results.
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