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Duhrsen U et al. – In aggressive non–Hodgkin lymphomas, the result of positron emission tomography (PET) with [18F]fluorodeoxyglucose performed after a few cycles of chemotherapy has been shown to correlate with long–term treatment outcome. The PETAL trial investigates whether a change in treatment protocol may improve the outcome of patients with a positive scan after two cycles of (R–)CHOP. In patients with a positive scan, relapses were six times more frequent than in patients with a negative scan.

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