Radiology Medical News about Osteoarthritis, Knee

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Meredith DS et al. – These results support an inter-relationship of multiple articular elements in the pathoanatomy of knee OA.

Methods

Cross-sectional study
Knee MRI scans from patients over 45 years old assessed using semi-quantitative knee MRI assessment form
Form included 6 distinct elements: cartilage, bone marrow lesions, osteophytes, subchondral sclerosis, joint effusion and synovitis
Each type of pathology graded using ordinal scale with value of zero indicating no pathology and higher values indicating increasingly severe levels of pathology
Principal dependent variable for comparison was mean cartilage disease score (CDS), which captured aggregate extent of involvement of articular cartilage
Distribution of CDS compared to individual and cumulative distributions of each articular element using Chi-squared test
Correlations between pathological change in various articular structures were assessed in Spearman correlation table

Results

Data from 140 patients were available for review
Cohort had median age of 61 years (range 45-89)
61% female
Cohort included wide spectrum of OA severity
Our analysis showed statistically significant trend towards pathological change involving more articular elements as CDS worsened
Comparison of CDS to change in severity of pathology of individual articular elements showed statistically significant trends towards more severe pathology as CDS worsened for osteophytes , bone marrow lesions , and subchondral sclerosis , but not joint effusion or synovitis