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Begg AC et al. – Expected trends for the future are: more signatures relevant to radiotherapy will be discovered; signatures will be refined and reduced to their essentials, such that genome–wide screening will give way to tailored signatures, quantifiable by routine non–array technology; more focus will be on assays predicting which pathway–specific radiosensitising drugs will be effective; more signatures will be subjected to validation in randomised trials; and proteomics, DNA sequencing and imaging methods will play progressively increasing roles.

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