Radiology Medical News about Cardiomyopathy, Hypertrophic

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Characteristics and Clinical Significance of Late Gadolinium Enhancement by Contrast-Enhanced Magnetic Resonance Imaging in Patients with Hypertrophic Cardiomyopathy
Circulation: Heart Failure, 10/27/09

Rubinshtein R et al. – In patients with HCM, presence of LGE on CE–MRI was common, and more prevalent among gene–positive patients. LGE was not associated with severe symptoms. However, LGE was strongly associated with surrogates of arrhythmia and remained a significant associate of subsequent SCD and/or ICD discharge after controlling for other variables. If replicated, LGE may be considered an important risk factor for sudden death in patients with HCM.

Exclusive Author Commentary
Bernard J. Gersh, 10/28/09

Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy is problematic and the majority of previously identified risk factors have a low predictive accuracy. Although sudden cardiac death is unpredictable and uncommon it is a catastrophic event and we need new risk factors. If this study is replicated by others it could be an important advance

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Electrocardiographic amplitudes: a new risk factor for sudden death in hypertrophic cardiomyopathy
European Heart Journal, 11/10/09 Relevance Score: 68%

Severe Left Ventricular Wall Thinning and Extensive Fibrosis Without Evolution to End Stage Disease in a Patient With Hypertrophic Cardiomyopathy
Journal of The American Society of Echocardiography, 10/12/09 Relevance Score: 67%

Cell Cycle Re-Entry and Mitochondrial Defects in Myc-Mediated Hypertrophic Cardiomyopathy and Heart Failure
PLoS ONE - Cardiovascular Disorders, 10/02/09 Relevance Score: 67%

Severe Hypertrophic Cardiomyopathy in an Infant with a Novel PRKAG2 Gene Mutation: Potential Differences Between Infantile and Adult Onset Presentation
Pediatric Cardiology, 10/02/09 Relevance Score: 67%

Diagnostic accuracy of extended-length electrocardiogram in differentiating between athlete's heart and hypertrophic cardiomyopathy
Journal of Electrocardiology, 10/29/09 Relevance Score: 66%