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Preoperative localization of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasonography in patients with breast cancer
British Journal of Surgery, 10/23/09

Sever A et al. – SLNs may be identified and localized before surgery using contrast–enhanced ultrasonography after injection of microbubbles.

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A. Sever , 11/08/09

In breast cancer patients the sentinel lymph node (SLN) is the first lymph node (or lymph gland) in which cancer cells would be found if they spread to the axillary (armpit) nodes. It is vital to find out if this spread has taken place. Up until now this could only be done at operation after injecting special dyes. Our research has shown for the first time ever that the SLN can be identified by ultrasound before surgery using a contrast enhancing agent called microbubbles. This will enable a targeted fine needle biopsy of the SLN which it is hoped will avoid the need for a second operation in most breast cancer patients. It may be possible to remove this node under ultrasound as an out-patient using special devices which are already available. In the longer term this technique may be used in other superficial cancers e.g. melanoma

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