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See Latest ArticlesExplorative study on the predictive value of systematic inflammatory and metabolic markers on weight loss in head and neck cancer patients undergoing radiotherapy
Supportive Care in Cancer, 10/20/09
Ehrsson YT et al. – HsCRP increased in response to RT for H&N cancer as a sign of irradiation-induced inflammation. Weight loss was not preceded by changes of the metabolic parameters, indicating that assessment of the blood markers used in this study is of little value. Regular body weight measurement and assessment of oral mucositis are feasible, cheap and important procedures to control the metabolic homeostasis during RT.
Methods- 27 patients evaluated
- Protocol included serial blood tests [hsCRP, albumin, insulin-like growth factor 1 (IGF-1), IGF binding protein 1 (IGFBP-1) and ghrelin], measurements of body weight and assessment of oral mucositis
- Mean nadir of weight loss observed at end of RT
- At time of diagnosis, mean hsCRP 5.2 ± 1.0 mg/L
- HsCRP significantly increased during RT and decreased during post-RT period
- Mean maximum hsCRP was 35.8 ± 8.5 mg/L, with 7 patients reaching > 40 mg/L
- Numerical decrease of albumin (by 18.2%) and only small changes in IGF-1, IGFBP-1 and ghrelin levels were observed
- None of metabolic parameters significantly associated with weight loss
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