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Fetal thickened nuchal soft tissues may first appear in the second trimester in Down syndrome
Journal of Clinical Ultrasound, 10/15/09
Zimmer EZ et al. – Obstetricians should be aware that a nuchal abnormality may first appear only at 14–16 weeks' gestation. Fetal karyotyping is advocated in these cases because of the high probability of Down syndrome.
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