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Timmerman E et al. – In a population of fetuses with enlarged NT there are significantly more males. Male fetuses with enlarged NT and normal chromosomes have an almost two–fold greater chance of a favorable outcome than females. The authors believe that a minimal degree of NT enlargement in male fetuses without genetic or structural anomalies may be interpreted as a feature of accelerated growth or, alternatively, as a maturational delay of the cardiovascular system more common in males, leading to moderately increased nuchal fluid accumulation.

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