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Burrell RC et al. – The labeled oxalate was first treated with aqueous base to give the mono–potassium salt of 2–methoxy–2–oxoacetate ([14C]–3), which was then reacted with oxalyl chloride to give [14C]–1 as a solution in dichloromethane. The overall radiochemical yield for this process was essentially quantitative, and [14C]–1 was found to be stable and easy to use in further synthetic manipulations.


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