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History, heresy and radiology in scientific discovery
Journal of Medical Imaging and Radiation Oncology (JMIRO), 10/05/09

McCredie J – The longitudinal reduction deformities follow the distribution of segmental sensory innervation of the limb skeleton, indicating neural crest as the target organ. Injury to one level of neural crest halts normal neurotrophism and deletes the dependent segment – a previously unrecognised embryonic mechanism that explains most non–genetic birth defects. The final common pathway is neural crest injury and failure of normal neurotrophism to result in longitudinal reduction deformities, for example, phocomelia.

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