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See Latest ArticlesProton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r
Magnetic Resonance in Medicine, 10/09/09
Le HC et al. – Metabolic changes, in particular of total choline intensity detected by proton magnetic resonance spectroscopic imaging, are consistent with the observed immunohistochemistry changes, tumor growth inhibition for CWR22r, and a constant prostate specific antigen level versus increasing prostate specific antigen for control CWR22. Metabolic changes in total choline by proton MRSI can be used as an early biomarker of response for advanced–stage prostate cancer in targeted therapy such as 17–allylamino, 17–demethoxygeldanamycin.
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