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Optimized MRI contrast for on-resonance proton exchange processes of PARACEST agents in biological systems
Magnetic Resonance in Medicine, 10/06/09
Li AX et al. – This predication was verified by experimental spectroscopic and imaging results from aqueous solution, bovine serum albumin phantoms, and a tissue phantom containing thulium–DOTAM (1,4,7,10–tetraazacyclododecane–1,4,7,10–tetraacetamide)–glycine–lysine. This model can be used to optimize sequence parameters to maximize in vivo on–resonance paramagnetic agent chemical exchange effects contrast.
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