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Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction
Magnetic Resonance in Medicine, 09/30/09

Holmes JH et al. – The proposed technique provides whole–lung three–dimensional imaging of respiration dynamics at high spatial and temporal resolution and compares well to the current standard, multidetector CT. While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions.

Exclusive Author Commentary
Sean B. Fain , 10/02/09

This work represents the first method capable of whole lung visualization of respiratory dynamics using MRI. The approach allows the visualization of ventilation changes during active respiratory maneuvers making the experiment more consistent with lung physiology. Techniques using hyperpolarized gas contrast agents are advancing rapidly and this research in general strives to bring image technology to bear on the non-invasive measurement of regional ventilation, perfusion, and gas exchange.

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