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Kim SW et al. – Although the biosynthesis of capsaicin is known to involve the condensation of vanillylamine and 8–methylnonenoic acid by capsaicin synthase, the mechanism of biosynthesis is still not fully understood. In this study, deuterium labelled versions of capsaicin and the precursor vanillylamine were synthesized in order to investigate the biosynthesis of capsaicin in hot peppers.

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