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Brain metabolic correlates of dopaminergic degeneration in de novo idiopathic Parkinson's disease
European Journal of Nuclear Medicine & Molecular Imaging, 09/09/09
Berti V et al. – Putaminal BPLS is an efficient parameter for exploring the correlations between PD severity and rCMRglc cortical changes. The correlation between dopaminergic degeneration and rCMRglc in several prefrontal regions likely represents the cortical functional correlate of the dysfunction in the motor basal ganglia–cortical circuit in PD. This finding suggests focusing on the metabolic course of these areas to follow PD progression and to analyze treatment effects.
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