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See Latest ArticlesThe effect of spironolactone on sweat and urinary sodium excretion during exercise in humans
Clinical Physiology and Functional Imaging, 09/04/09
Lee NVL et al. – These results demonstrate that spironolactone caused the expected natriuresis, but greater sodium excretion was not observed in the sweat gland. Since the mineralocorticoid receptors in the sweat gland were not antagonized by spironolactone in the same manner as those in the kidney, this suggests that different isoforms of the MR exist in the kidney and the sweat gland of humans.
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