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Wang JL et al. – This compound series was found to have potential for producing a suitable 18F–radiolabeled PET radiotracer for SERT. Compound 4, the pentoxy derivative, had the lowest brain uptake and target–to–nontarget ratio. Compound 3, the butoxy derivative, had a lower target–to–nontarget ratio than compounds 1 and 2. Compounds 1 and 2 both hold promise as SERT radioimaging agents, but because of cost limitations, only compound 2 will be evaluated in further studies.



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