Radiology Medical News about 18F-FDDNP

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Relationship of Cerebrospinal Fluid Markers to 11C-PiB and 18F-FDDNP Binding
The Journal of Nuclear Medicine, 08/19/09

Tolboom N et al. – The good agreement between these 2 different types of biomarkers provides converging evidence for their validity. The inverse association between 11C–PiB and CSF tau A1–42 confirms that 11C–PiB measures amyloid load in the brain. The positive association between 18F–FDDNP and CSF tau suggests that at least part of the specific signal of 18F–FDDNP in AD patients is due to tangle formation.

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