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ERP generator anomalies in presymptomatic carriers of the Alzheimers disease E280A PS-1 mutation
Human Brain Mapping, 08/20/09

Bobes MA et al. – Compared to controls, the symptomatic–carriers presented a similar anatomical shift in the distribution of N400 generators to that found in presymptomatic–carriers, albeit with a larger reduction in generator strength. The redistribution of N400 generators in presymptomatic–carriers indicates that early focal degeneration associated with the mutation induces neural reorganization, possibly contributing to a functional compensation that enables normal performance in the semantic task.

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