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Dickson JC et al. – The number of EM–equivalent iterations used in OS–EM reconstruction influences the quantification of DaTSCAN studies because of incomplete convergence and possible bias in areas of low activity due to the nonnegativity constraint in OS–EM reconstruction. Nevertheless, OS–EM using 100 EM–equivalent iterations provides the best linear discriminatory measure to quantify the uptake in DaTSCAN studies.

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