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S-Phase Cells Are More Sensitive to High-Linear Energy Transfer Radiation
International Journal of Radiation Oncology*Biology*Physics, 07/16/09
Wang H et al. - S-phase cells are more sensitive to high-LET IR than nonsynchronized and G2-phase cells, because of the following mechanism: it is more difficult for Ku protein to bind to high-LET IR-induced DNA DSBs in S-phase cells than in cells at other phases, which results in less efficient NHEJ.
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